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Reference Details
Frentz, Dineke, Boucher, Charles A. B. and van de Vijver, David A. M. C. (2012), "Temporal Changes in the Epidemiology of Transmission of Drug-Resistant HIV-1 across the World", AIDS Reviews.

Abstract:
A substantial number of studies have been performed across the world to determine transmitted drug resistance. Large variations between different parts of the world can be expected because of differences in availability over time of treatment. Time trend analyses are often not possible because of small numbers of included patients. In this review, we present the available data on the transmission of drug-resistant HIV, with a major emphasis on the time trends of drug resistance prevalences. We identified relevant literature by searching in PubMed through September 2009. Studies were grouped, according to the year of data collection, into the following time periods: 2003. We selected a total of 215 studies, which included 43,170 patients. The following prevalences of transmission of drug-resistant HIV were found, in rank order: North America (12.9%), Europe (10.9%), Latin America (6.3%), Africa (4.7%), and Asia (4.2%). Changes over time in particular drugs classes were found in all parts of the world. Nucleoside reverse transcriptase inhibitor resistance declined over time in North America (p = 0.03), Europe (p e in North America (p .001), Latin America (p .01). This paper gives a complete overview of the epidemiology of resistance of antiretroviral drugs in drug-naive patients worldwide. The time trends that were observed seem to reflect changes in describing prescriptions over time. Changes include the more wide-spread use of antiretroviral drugs in developing countries and the development of therapies from low-active mono-therapies to highly active antiretroviral regimens in the industrialized countries.

Keywords:
HIV-1. Drug resistance mutations. Resistance prevalence. Transmitted drug resistance.

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Highlights

This article is 'Highly accessed'  (total accesses to this article since publication: 1197) relative to age  in  BioMed Central:
Increasing risk behaviour can outweigh the benefits of antiretroviral drug treatment on the HIV incidence among men-having-sex-with-men in Amsterdam
Shan Mei, Rick Quax, David VAN de Vijver, Yifan Zhu and P.m.a. Sloot BMC Infectious Diseases, 11:118   (11 May 2011)

As of August 27, the most downloaded/accessed paper in BMC Systems Biology is: D. van Dijk et al.: Identifying potential survival strategies of HIV-1 through virus-host protein interaction networks, BMC Systems Biology, vol. 4, nr 1 pp. 96+17. 2010.

This paper received the ICCS best paper award 2010:
N. Zarrabi et al.: Modeling HIV-1 intracellular replication,
Procedia Computer Science vol. 1, nr 1 pp. 555-564. Elsevier B.V., Amsterdam, May 2010.

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